Blood cells in chronic fatigue syndrome are drained of energy

From New Scientist, Daily News, 3 November 2017

“A PhD student at Newcastle University in the UK, she has just published a paper demonstrating that white blood cells in people with the disease are as listless as the people themselves often feel. “Now we’ve shown there’s a physiological difference, it could explain the whole-body fatigue shown by patients,” she says.

The finding adds to mounting evidence that the disorder has a biological explanation, and raises the prospects for new treatments and diagnostic tests.

For many years, arguments have raged over whether CFS — also known as myalgic encephalomyelitis, or ME — has a physiological or psychological basis. But the latest research comparing samples of peripheral blood mononuclear cells (PBMCs) from 52 people with the condition and 35 without has reinforced the case for a biological explanation.

Less mighty mitochondria

Across almost all measures of energy capacity, the cells from people with CFS were weaker compared with their healthy counterparts. If other cells are equally compromised, it could explain why people with the condition are often bed- or wheelchair-bound for months, and struggle with even modest physical exertion.”

Related Links

See the original research report at PLOS One: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186802

Read a summary of this research from the ME Association UK: http://www.meassociation.org.uk/2017/11/new-scientist-blood-cells-in-chronic-fatigue-syndrome-are-drained-of-energy-04-november-2017/

People With Chronic Fatigue Syndrome Are Exhausted at a Cellular Level, Study Shows: https://www.sciencealert.com/chronic-fatigue-syndrome-low-energy-production-in-cells-metabolic-disease

Blood cells in chronic fatigue syndrome are drained of energy: https://www.newscientist.com/article/2152357-blood-cells-in-chronic-fatigue-syndrome-are-drained-of-energy/

Cellular Energy Production Takes Big Hit in Chronic Fatigue Syndrome (ME/CFS) Study: https://www.healthrising.org/blog/2017/11/11/cellular-energy-hit-chronic-fatigue-study/

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